Expression pattern of human ATP ‐binding cassette transporters in skin
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منابع مشابه
Expression pattern of human ATP-binding cassette transporters in skin
ATP-binding cassette (ABC) transporters transport a variety of substrates across cellular membranes coupled with hydrolysis of ATP. Currently 49 ABC transporters consisting of seven subfamilies, ABCA, ABCB, ABCC, ABCD, ABCE, ABCF, and ABCG, have been identified in humans and they are extensively expressed in various tissues. Skin can develop a number of drug-induced toxicities' such as Stevens-...
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Background The development of chemoresistance still is a major problem in cancer therapy. Mainly, impact of chemotherapy is based on the upregulation of ATP-binding cassette (ABC) transporters, which correlates with bad prognosis and less chemotherapeutic success. Previously, we could show that the HMG-CoA reductase inhibitor simvastatin is able to inhibit the most prominent ABC transporter ABC...
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ژورنال
عنوان ژورنال: Pharmacology Research & Perspectives
سال: 2013
ISSN: 2052-1707,2052-1707
DOI: 10.1002/prp2.5